The reference site for Amoxapine

Amoxapine (pronounced: a-mox-a-peen. Notable brand names include: Asendin, Asendis, Defanyl, Demolox) is a tetracyclic antidepressant of the dibenzoxazepine family, though it is often classified as a secondary amine tricyclic antidepressant.


Amoxapine is in a class of drugs called tricyclic antidepressants. It affects chemicals in the brain that may become unbalanced and cause depression.
This medicine is used to relieve symptoms of depression such as feelings of sadness, worthlessness, guilt, loss of interest in daily activities, changes in appetite, tiredness, sleeping too much, insomnia, and thoughts of death or suicide.


Brand Name(s): Asendin
CAS nº: 14028-44-5
(ah mock sa peen)

Product Info

The sections below will provide you with more specific information and guidelines related to amoxapine and its correct use. Please read them carefully.

FDA Information

Amoxapine was approved by the FDA in September 1980. A prescription is required for this medicine.
Please visit the official site of the FDA for further information.

Why is this medication prescribed?

This medicine is used in the treatment of depression, panic disorders and bipolar disorder.
Amoxapine is in a class of drugs called tricyclic antidepressants. Tricyclic antidepressants work by changing the balance of naturally occurring chemicals in the brain that regulate the transmission of nerve impulses between cells.
Amoxapine acts primarily by increasing the concentration of norepinephrine and serotonin (both chemicals that stimulate nerve cells) and, to a lesser extent, by blocking the action of another brain chemical, acetylcholine.

Other uses for this medicine

This medication may also be used to treat nerve pain and sleeping problems (insomnia).
Nevertheless, it is important that you talk to your doctor about the possible risks of using this drug for your particular condition.

Dosage and using this medicine

Amoxapine comes as a tablet to be taken orally. It is usually taken one or more times a day and may be taken with or without food.
More importantly, take this medicine exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass (8 oz) of water.
It may take up to 4 weeks or more before you start feeling improvements, but do not stop taking this medicine without first talking to your doctor.

What special precautions should I follow?

Please inform your doctor about your medical history, especially if you have a history or family history of psychiatric disorders (e.g., bipolar/manic-depressive disorder), history or family history of suicide attempts, glaucoma, prostate problems, decreased urine output, thyroid disease, breathing problems, seizure problems, alcohol use, heart disease, liver or kidney disease, as well as any drug allergies.

Moreover, tell your doctor about the medicines you take, especially if you take any of the following: clonidine, guanadrel, guanethidine, MAO inhibitors (e.g., furazolidone, linezolid, phenelzine, selegiline, tranylcypromine), cimetidine, SSRIs (e.g., fluoxetine, sertraline), warfarin, carbamazepine, certain diet pills (e.g., phentermine), adrenaline-type drugs (e.g., dopamine, ephedrine, epinephrine, pseudoephedrine, phenylephrine, isoproterenol – some of which may be found in cough and cold or asthma products), narcotic pain medications (e.g., codeine), cisapride, St John’s wort, heart rhythm drugs (e.g., quinidine, flecainide, propafenone), phenothiazines (e.g., Chlorpromazine®), any other prescription or nonprescription drugs you take.

Amoxapine may increase heart rate and stress on the heart. It may be dangerous for people with cardiovascular disease, especially those who have recently had a heart attack, to take this drug or other antidepressants in the same pharmacological class. In rare cases in which patients with cardiovascular disease must receive amoxapine, they should be monitored closely for cardiac rhythm disturbances and signs of cardiac stress or damage.

Use caution when engaging in tasks requiring alertness such as driving or operating machinery.

Additionally, you should limit alcohol consumption as it may increase the drowsiness and dizziness effects of this drug.

Limit exposure to hot weather as it may lead to heat stroke.

Caution is advised when using this drug in the elderly, because they may be more sensitive to the effects of the drug (e.g., confusion may occur or worsen).

This drug should be used during pregnancy only if clearly needed. Discuss the risks and benefits with your doctor. So too, this drug may be excreted into breast milk. The effects on the infant are not known at this time. Consult your doctor before breast-feeding.

What should I do if I forget a dose?

If you take several doses per day, take the missed dose as soon as you remember it and take any remaining doses for that day at evenly spaced intervals. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule.

If you take amoxapine once a day at bedtime and do not remember to take it until the next morning, skip the missed dose.
Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

If you experience any of the following serious side effects, stop taking amoxapine and contact your doctor immediately or seek emergency medical treatment:
an allergic reaction (difficulty breathing, closing of the throat, swelling of the lips, face, or tongue, or hives)


a fast or irregular heartbeat

a heart attack

high blood pressure (blurred vision, severe headache)

difficulty urinating

fever with increased sweating, muscle stiffness, or severe muscle weakness
Other, less serious side effects may be more likely to occur. Continue to take amoxapine and talk to your doctor if you experience:
drowsiness or dizziness

dry mouth and eyes


mild tremor


mild agitation, weakness, or headache

ringing in the ears


loss of weight or appetite
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What storage conditions are needed for this medicine?

Always keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).
Additionally, please remember to throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

In case of an emergency/overdose

In the case of an overdose, call your local poison control center on 1-800-222-1222. However, if the victim has collapsed or is not breathing, please call the local emergency services on 911.
Symptoms of overdose may include:





low blood pressure (dizziness, fatigue, fainting)

Product Images


Below you will find images and specific information on the principal types of amoxapine that exist, including their respective brand name(s), strength, inscription codes, manufacturers and/or distributors.
The information below includes general information and guidelines for patients taking this medication and should never be used to substitute professional medical advice that can be provided by a qualified physician or family doctor.

Strength(s): 25 MG
Imprint: DAN 25 | 5713
Manufacturer: WATSON LABS.

Strength(s): 50 MG
Imprint: DAN 50 | 5714
Manufacturer: WATSON LABS.


Strength(s): 150 MG
Imprint: DAN 150 | 5716
Manufacturer: WATSON LABS.


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